The title of the film, Mumbai Salsa, refers to a lounge bar in Mumbai. Apart from Vir and Amruta, Manjari Fadnis, Raymond Irani, Indraneil Sengupta, Dilip Thadeshwar, Neelam Chauhan and Linda Arsenio are also making their debut in the film.

The film shows how the race of life changes people's perceptions and why they spend more time in pubs and nightclubs apart from their offices and homes. Mumbai Salsa is one such pub in Mumbai where the lives of these characters change for ever.